Posted by: miriamjang | March 20, 2008

The Effectiveness of the differing Routes of Adminsitration of Methyl B12

Here is an important summary of the effectiveness of administering methyl B12 by transdermal ( cream on the skin), oral, nasal spray and painless subcutaneous shots. Methyl B12 is important in that it donates a methyl group which is necessary for many biochemical reactions in the body. Dr Neubrander’s study has found that methyl B123 shots are very helpful in many Autistic kids. I have all my patients on these shots. The needles are so tiny that they are virtually painless. If I forget to give my son a shot, he will literally go to the fridge and take it out and hand it to me to administer it to him. We have found that these shots help many Autistic kids improve in their Autistic symptoms. Some kids do experience a period of hyperactivity which usually goes away after 3-6 weeks—-I know, hard to take…..The protocl is to give the shot every day every other day or every 3 days. Different supplements are sometimes added to the methyl B12 shots as well. I usually do not add anything else as I like to keep the volume of the shot small as to keep the painlessness of them intact.

Here is Dr Neubrander’s summary of the effectiveness of the different routes of administering this methyl B12:

Transdermal methyl B12 doesn’t work to any significant degree. Once again, we have studied its use when added alone and compared to other methods of administration and evaluated by the PDRF at the 6th week. Both from our own in-house studies and a private clinician survey from those who use MB12 the closest to the way I do, note the following:

Range of response and intensity of responses for MB12: (note that the comparison is against SQ MB12 as the standard so that there is no argument that “I disagree because I saw this or that response by X, Y, or Z method of administration.” I am not reporting whether a response occurred or not but how the response rate and intensity compared to what parents and clinicians really want to see — excellent results)

a) Subcutaneous shots: Range of response — 80% to 94%; global responses out of 135 possible –> average 30-45 or more on initial 6 week follow-up.
b) Nasal: Range of response — 25% to 60% (most clinicians said 25% to 30%), far less global responsiveness with less overall intensity of responses when present. Out of several hundred families who were initially taking SQ MB12 and then given nasal MB12, only 2 remain on the nasal and all have spontaneously requested on their own to return to the injections.
c) Transdermal: Range of response — 5% to 8%; minimal global responsiveness; minimal intensity of response when present.
d) Oral: Range of response — 3% to 5%; minimal global responsiveness; almost insignificant intensity of response when present.
e) Sublingual: Essentially not able to be used in children with autism and is therefore ineffective. For those who we were able to study, the effect was approximately that of oral or transdermal which was not impressive when compared to SQ.
f) Though an unpopular stance, after evaluating over 100 patients who came to our clinic on SQ MB12 shots using the correct dose and base concentration and injection technique as I teach but who were also using TMG, they did not see significant benefit until they stopped using the TMG while continuing MB12 and everything else unchanged for my “no other changes for your 1st 6 week clinical trial”. This concept is not far fetched when one considers that TMG can up-regulate BHMT and subsequently, in order to reach total body equilibrium, will then down-regulate total methionine synthase. According to Dick, methionine synthase in the brain is different than in the body and therefore we will want to do everything possible to keep as much MS in the brain (and
body) as possible. I COULD BE WRONG on the terminology and strict biochemistry, but the observation has been repeated hundreds of times with the same effects clinically. Therefore I will let the scientists argue about semantics but will not defer from my position that TMG blocks the effects of MB12, at least according to the protocols I use and when evaluated the same way using the PDRF after no changes are allowed for 6 weeks. I think it is very scientific for us to think that what happens in the brain is not the same thing that happens in the body. Total body methylation does not necessarily match clinicially with total brain methylation. The biochemical charts we all use do not differentiate between what’s happening in the total body vs. what’s happening in only a small part of itself, that being the brain.

This is a medical disclaimer: Please remember that this not meant as medical advice but as a desire to share information. Please always implement treatments under medical supervision. We are cannot be held liable for any of this information


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