Posted by: miriamjang | February 21, 2008

Oxidative Stress and Neurotoxicity

Even though this article does not specify Autism, we have found that anything that has to do with Neurotoxicity does pertain to Autism:

Article available for the masses:
http://pubs.acs.org/cgi-bin/sample.cgi/crtoec/2008/21/i01/pdf/tx700210j.pdf

Chem Res Toxicol. 2008 Jan 21;21(1):172-88. Epub 2007 Dec 4.

Oxidative stress and neurotoxicity.

Sayre LM, Perry G, Smith MA.
Departments of Chemistry, Pathology, and Environmental Health Sciences, Case Western Reserve University, Cleveland, Ohio 44106, and College of Sciences, University of Texas at San Antonio, San Antonio, Texas 78249 LMS3@case.edu.

There is increasing awareness of the ubiquitous role of oxidative stress in neurodegenerative disease states. A continuing challenge is to be able to distinguish between oxidative changes that occur early in the disease from those that are secondary manifestations of neuronal degeneration. This perspective highlights the role of oxidative stress in Alzheimer’s, Parkinson’s, and Huntington’s diseases, amyotrophic lateral sclerosis, and multiple sclerosis, neurodegenerative and neuroinflammatory disorders where there is evidence for a primary contribution of oxidative stress in neuronal death, as opposed to other diseases where oxidative stress more likely plays a secondary or by-stander role. We begin with a brief review of the biochemistry of oxidative stress as it relates to mechanisms that lead to cell death, and why the central nervous system is particularly susceptible to such mechanisms. Following a review of oxidative stress involvement in individual disease states, some conclusions are provided as to what further research should hope to accomplish in the field.
PMID: 18052107

This is a medical disclaimer: Please remember that this not meant as medical advice but as a desire to share information. Please always implement treatments under medical supervision. We are cannot be held liable for any of this information.

 

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